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science with tom - plasmid rap lyrics

(chorus)
a plasmid is a circle of dna with lots of parts
bacteria make’em but scientists can break’em apart
so now i’m so glad, that we can design em a la carte
so they should be shared, be shared, be shared
plasmids turn genetics into art
(verse 1)
thinking about playing with genes
what if we could change em and spread em like memes?
what if we could rearrange em to study proteins?
well these plasmids got us all letting off s.t.e.a.m
it’s lit
so here’s what a plasmid is
circle of dna from bacterias
it’s got restriction sites where we slash with scissors
called restriction enzymes that let us match and mix
or mix and match gene from a new species
just put in a promoter and express with ease
and with a sight of origin it can replicate
to make copies of your plasmid and generate
yeah they’re great + easy to manipulate
but just think, what if they could infiltrate
not just bacteria but other life
we’d be pretty much wielding a genetic knife
(chorus)
a plasmid is a circle of dna with lots of parts
bacteria make’em but scientists can break’em apart
so now i’m so glad, that we can design em a la carte
so they should be shared, be shared, be shared
plasmids turn genetics into art
(verse 2)
ok
snip
poke
test cells
pipette
run gels
ligate
incubate
die? wait
survive? great!
now each ring has a power like frodo done told me (baggins)
and i’ve got so many you can call me kobe (swaggin’)
favorite application is to make ‘em glowing
which helps you find out where molecules are going
all i do is insert gfp
in the right type of ring with the right set of genes
depending how i do it i’ll be glowing green
either all the time or when i want to
like maybe just in cells of a certain type
or biosensor for molecules floating by
and i can do this in fish, i can do this in a beagle
i could do it to you (but that’d be illegal)
but we do it to research the state of nature
golden age of biotech and its applications
from medicine to food to security
to learning about the fundamentals of biology
(outro)
plasmids
what new genes can we add in?
what new questions we askin’?
plasmids, plasmids, plasmids
what new genes can we add in? what new questions we asking?
plasmids
plasmids

- science with tom lyrics

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