pillars of cacophony – necrosis lyrics
cells suffer necrosis
when exposed to extreme environmental stimuli
adverse and excessive
when deleterious mutations encoded in the dna
result in ultra+structural and morphological features
accompanied by extensive swelling of the cell
that contrasts sharply those
undergoing apoptosis
terminal
irreversible
absolute
the fate is sealed
a passive process not requiring synthesis
minimal energy requirements
not regulated by any homeostatic mechanism
the dominant concept
that has permeated
stipulated that necrosis
is merely the chaotic breakdown
of a cell under intolerable conditions
terminal
irreversible
absolute
the fate is sealed
once triggered, it is inevitable
first, intracellular calcium increases
next, calpains become activated
finally, death
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